Catalog Number

553863

Brand

BD Pharmingen™

Name

PNAd Carbohydrate Epitope

Alias

CD62L Ligand

Concentration

0.5 mg/ml

Size

0.5 mg

Regulatory Status

 RUO

Clone

MECA-79

Format

Purified

Isotype

IgM, κ

W.B. Positive Control

none

Immunogen

Collagenase-dispersed BALB/c lymph node stroma

Strain Host

WF

Reactivity

QC Testing : Mouse

Applications

Blocking	- Reported
Immunohistochemistry-frozen	- Reported
Immunohistochemistry-paraffin	- Routinely Tested
Immunohistochemistry-zinc-fixed	- Reported
Immunoprecipitation	- Reported
Western Blot	- Reported

Clone - References

1. Streeter, P.R., B.T.N. Rouse, and E.C. Butcher. 1988. Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes. J. Cell Biol. 107: 1853 - 1862.2. Hemmerich, S, E.C. Butcher, and S.D. Rosen. 1994. Sulfation-dependent recognition of high endothelial venules (HEV)-ligands by L-selectin and MECA 79, an adhesion-blocking monoclonal antibody. J. Exp. Med. 180: 2219 - 2226.3. Berg, E.L., M.K. Robinson, R.A. Warnock, and E.C. Butcher. 1991. The human peripheral lymph node vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor. J. Cell Biol. 114: 343 - 349.4. Michie, S.A., P.R. Streeter, P.A. Bolt, E.C. Butcher, and L.J. Picker. 1993. The human peripheral lymph node vascular addressin. An inducible endothelial antigen involved in lymphocyte homing. Am . J. Pathol. 143: 1688 - 1698.5. Faveeuw, C., M.-C. Gagnerault, and F. Lepault. 1994. Expression of homing and adhesion molecules in infiltrated Islets of Langerhans and salivary glands of nonobese diabetic mice. J. Immunol. 152: 5969 – 5978.6. Maly, P., A.D. Thall, B. Petryniak, C.E. Rogers, P.L. Smith, R.M. Marks, R.J. Kelly, K.M. Gersten, G. Cheng, T.L. Saunders, S.A. Camper, R.T. Camphausen, F.X. Sullivan, Y. Isogai, O. Hindsgaul, U.H. von Andrian, and J.B. Lowe. 1996. The a(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Cell 86: 643 - 653.7. Diacovo, T.G., K.D. Puri, R.A. Warnock, T.A. Springer, and U.H. von Andrian. 1996. Platelet-mediated lymphocyte delivery to high endothelial venules. Science 273: 252 - 255.8. Puri, K.D., E.B. Finger, G. Gaudernack, and T.A. Springer. 1995. Sialomucin CD34 is the major L-selectin ligand in human tonsil high endothelial venules. J. Cell Biol. 131: 261 - 270.