详细描述

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape. SLLNATAIAV had a significantly positive association with HLA A*02 it was recognized by 23/134 A*02-positive subjects and 9/190 A*02-negative subjects.