Alexa Fluor® 647 anti-human CD126 (IL-6Rα)；Clone#：BL-126Host/Isotype：Mouse IgG1
详细描述
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 Human peripheral blood lymphocytes stained with CD3 (UCHT1) FITC and BL-126 Alexa Fluor®647 (top) or mIgG1,κ Alexa Fluor®647 isotype control (bottom) 
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| Description: |
CD126 is an 80 kD IL-6 receptor α chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on plasma cells, T cells, activated B cells, monocytes, hepatocytes, epithelial cells, and fibroblasts. Functional IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself, but associates with the α-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. Soluble form of CD126 has been found in human serum. |
| Other Names: |
IL-6 Receptor α chain, IL-6R |
| Structure: | Ig superfamily, associates with IL-6Rβ chain (CD130, gp130), 80 kD |
| Distribution: | Plasma cells , T cells, monocytes, hepatocytes, activated B cells |
| Ligand Receptor: | IL-6 |
| Bioactivity/Activities: | Stimulates T cells, B cells, hematopoietic precursor proliferation and differentiation |
| Antigen References: |
1. Taga T, et al. 1997. Annu. Rev. Immunol. 15:797. |
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