Alexa Fluor® 647 anti-human CD186 (CXCR6);Clone# TG3/CXCR6
详细描述
|
 Human peripheral blood mononuclear cells stimulated with IL-2 for 9 days and then stained with CD3 (UCHT1) PE and TG3/CXCR6 Alexa Fluor® 647 |
| Description: |
CXCR6 is a chemokine receptor that binds CXCL16. It is expressed in Th1 inflammatory diseases such as rheumatoid arthritis (3) and Grave’s disease (4) among others. Th1 cells isolated from the bronchoalveolar lavage of patients with sarcoidosis and T-cell alveolitis coexpressed CXCR3 and CXCR6. The CXCR6 ligand CXCL16 was abundantly expressed by macrophages infiltrating sarcoid tissue and/or forming the granuloma core (5). Recent data showed that CXCR6 is expressed on polymorphonuclear neutrophils in pancreatic carcinoma and in acute localized bacterial infections. CXCR6 is not constitutively expressed on PMN, but is up-regulated under inflammatory conditions and mediates migration of CXCR6-positive PMN (6). Fetus-derived trophoblasts can attract T cells, gamma delta T cells, and monocytes by producing CXCL16 and interaction with CXCR6 on these cells, leading to forming a specialized immune milieu at the maternofetal interface (7). |
| Other Names: |
CXCR6, BONZO, CD186, STRL33, TYMSTR |
| Structure: | GPCR, seven transmembrane receptor |
| Distribution: | Th1, T-cytotoxic 1 cells, γδ T cells, NK cells, and monocytes |
| Function: | The receptor CXCR6 is abundantly expressed by Th1-polarized effector/memory lymphocytes accumulating at inflammatory sites. Priming of naive T cells by dendritic cells induces expression of CXCR6 on T cells. IL-12 enhances this dendritic cell-dependent upregulation, while IL-4 inhibits it (1). In addition, stimulation with IL-15 up-regulated the expression of CXCR6 on peripheral blood T cells (2). |
| Ligand Receptor: | CXCL13 |
| Antigen References: |
1) Kim CH, et al. 2001. J Clin Invest 107:595. |
This product is provided under an agreement between Life Technologies Corporation and Sony Biotechnology Inc. and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications, and corresponding non-U.S. equivalents, owned by and/or licensed to Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product in research and/or development conducted by the buyer (whether the buyer is an academic or for profit entity). The buyer cannot sell or otherwise transfer (a) this product (b) its components or (c) materials made using this product or its components to a third party or otherwise use this product or its components or materials made using this product or its components for Commercial Purposes. Commercial Purposes means any activity by a party for consideration and may include, but is not limited to (1) use of the product or its components in manufacturing, (2) use of the product or its components for therapeutic, diagnostic or prophylactic purposes, or (3) resale of the product or its components, whether or not such product or its components are resold for use in research. For information on purchasing a license to this product for any other use, contact Life Technologies Corporation, Molecular Probes Detection Technologies, Attn: Business Development, 29851 Willow Creek Road, Eugene, OR 97402, USA, Tel: (541) 465-8300. Fax: (541) 335-0504. |
