详细描述

MMPSense® 750 FAST Fluorescent Imaging Agent

MMPSense 750 FAST is an activatable fluorescent imaging agent comprising a novel architecture termed F.A.S.T. (Fluorescent Activatable Sensor Technology), that confers an improved pharmacokinetic profile with earlier imaging time points. This architecture offers higher target specific signal with reduced background while also reducing the optimal imaging time after injection.

MMPSense 750 FAST is a matrix metalloproteinase (MMP) activatable agent that is optically silent upon injection and produces fluorescent signal after cleavage by disease related MMP’s. Activation can occur by a broad range of MMP’s including MMP 2, 3, 7, 9, 12, and 13.

MMP activity is involved in many disease-related processes including cancer progression, invasion and metastasis, rheumatoid arthritis, pulmonary diseases and areas of cardiovascular disease. MMPSense 750 FAST may be used to monitor the progression of these diseases or to evaluate the potential therapeutic efficacy of drugs targeting the underlying mechanisms involved in these diseases.

“For laboratory use only. This product is intended for animal research only and not for use in humans.”